Present state of intestinal transplantation in Japan
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In brief
In brief
This Japanese registry study reports outcomes of 42 intestinal transplantations performed through 2022, predominantly in pediatric patients with intestinal failure. Results show 10-year survival of 59%, with 90% achieving complete independence from parenteral nutrition and excellent quality of life post-transplant.
Written by the GCMD Library team from the article.
Abstract
Introduction
Intestinal transplantation (ITx) is the ultimate treatment for intestinal failure (IF). In Japan, most cases of IF are a result of pediatric disease, including secondary or congenital intestinal disease or allied disorders of Hirschsprung’s disease. Here, we report the results of the Japanese ITx registry.
Methods
A web-based survey form was completed. We investigated the number, age, sex, indication, surgical procedure, immunosuppressants, postoperative course, and the effects of transplantation in patients who underwent cadaveric or living-donor ITx.
Results
By the end of 2022, 42 cases of ITx have been performed in 38 patients in Japan. The donor sources included cadavers (29 cases) and living donors (13 cases). The surgical method was isolated ITx (N = 40) and combined liver and ITx (n = 2). Survival rates were 92%, 73%, and 59% at 1 year, 5 years, and 10 years, respectively. Ninety percent of patients completely discontinued parenteral nutrition. Approximately 80% of the patients had a performance status of 1 or less, indicating that the QOL of patients after ITx was extremely good.
Conclusion
The results of ITx are acceptable to treat IF patients and the QOL after transplantation is also good.