Prenatal diagnosis at different gestational times and clinical features of choledochal cysts: a single tertiary center report
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In brief
In brief
This retrospective study of 218 prenatally diagnosed choledochal cyst cases found that earlier prenatal detection (≤27 weeks gestation) correlates with larger cyst size at surgery and higher rates of neonatal jaundice and liver dysfunction. Findings suggest timing of prenatal diagnosis may predict disease severity and clinical presentation in affected infants.
Written by the GCMD Library team from the article.
Abstract
Purpose
This study aimed to evaluate the effect of prenatal diagnosis at different gestational times on the clinical features of patients with choledochal cysts (CDCs).
Methods
Medical records of patients with prenatally diagnosed CDCs admitted to our hospital (April 2013–April 2018) were retrospectively reviewed. The clinical characteristics and pathological CDC features were analyzed.
Results
Two hundred eighteen cases were included. Patients were divided into two groups. Group 1 and group 2 had a prenatal diagnosis at ≤ 27 weeks of gestation (second trimester of gestation, n = 157) and > 27 weeks (third trimester of gestation, n = 61), respectively. The incidence of jaundice and the TBIL, IBIL and GGT levels were higher in Group 1 (P = 0.021, P = 0.029, P = 0.042, P = 0.007, respectively). The maximum cyst diameter at the time of surgery was larger in Group 1 (P = 0.015). An association study showed that the time of prenatal diagnosis was negatively correlated with the maximum cyst diameter both postnatally (r = − 0.223, P = 0.001) and at the time of surgery (r = − 0.268, P < 0.001).
Conclusion
Unlike patients diagnosed at a late prenatal age, patients diagnosed at an early prenatal age tend to present clinical symptoms (jaundice, manifested as high indirect bilirubin), hepatic function damage, and large cysts at the time of surgery.