Predictors of outcomes in infants with gastroschisis treated with a preformed silo
link.springer.com shows its articles on its own site.
Read the article on link.springer.com ↗Article · Dec 2024 · 1 min read
In brief
In brief
This retrospective study of 77 infants with gastroschisis managed using preformed silos achieved 100% survival over a 10-year period. Sepsis and complex gastroschisis significantly prolonged hospital stay and parenteral nutrition duration, while early physiological parameters and birth location did not predict outcomes.
- Preformed silo management achieved 100% survival in 77 gastroschisis infants over 10 years at a tertiary NICU.
- Early physiological parameters (lactate, base excess, toe-core gap) did not predict length of stay or parenteral nutrition duration.
- Sepsis and complex gastroschisis significantly increased both hospital stay and parenteral nutrition requirements (p<0.001).
- Median hospital stay was 37 days with 28 days of parenteral nutrition for gastroschisis managed with preformed silo.
- Place of birth (inborn vs outborn) did not significantly affect clinical outcomes in gastroschisis patients.
Written by the GCMD Library team from the article.
Abstract
Purpose
To describe the outcomes of infants with gastroschisis treated with a preformed silo (PFS) and determine whether routinely measured early physiological parameters, sepsis (blood culture positive), gastroschisis complexity or location of birth influenced the length of stay (LOS) and duration of parenteral nutrition (PN).
Methods
Infants cared for in a tertiary surgical neonatal intensive care unit during a 10-year period were identified.
Results
Seventy-seven infants were assessed [median gestational age 36 + 6 (IQR 35 + 3 to 38 + 0)] weeks. All survived; 82% were inborn. The median LOS was 37 (IQR 28–76.5) days and duration of PN was 28 (IQR 21–53) days. In the first 72 h, the worst median lactate, base excess and ‘toe-core’ gap were 4.2 (IQR 3.0–5.8) mmol/l, -7.0 (IQR − 5.55 to − 9.35), 3.4 (IQR 3.0–4.2) °C respectively. There were no significant correlations between early physiological parameters or place of birth and LOS or PN days, but sepsis (n = 18 infants) and complex gastroschisis (n = 13 infants) were associated with an increased LOS and PN duration (both p < 0.001).
Conclusions
Survival was 100% in infants with gastroschisis who were managed with PFS, sepsis and gastroschisis complexity were associated with a longer hospital stay and duration of parenteral nutrition.
Level of Evidence (I-V): IV.