Predictors of long ECMO runs for congenital diaphragmatic hernia
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Read the article on jpedsurg.org ↗Article · Mar 2020 · 1 min read
In brief
In brief
Analysis of 4,730 CDH infants from the ELSO Registry (2000-2015) identifies risk factors for prolonged ECMO runs (≥14 days). On-ECMO surgical repair showed the strongest association with extended support duration (OR 3.72), informing clinical decision-making for timing of CDH repair in critically ill neonates.
Written by the GCMD Library team from the article.
Background
Although longer ECMO run times for patients with congenital diaphragmatic hernia (CDH) have been associated with worse outcomes, a large study has not been conducted to examine the risk factors for long ECMO runs.
Methods
The Extracorporeal Life Support Organization (ELSO) Registry from 2000 to 2015 was used to identify predictors of long ECMO runs in CDH patients. A long run was any duration of ≥14 days. Multivariable logistic regression models were used to examine the association between demographics, pre-ECMO blood gas/ventilator settings, comorbid conditions, and therapies on long ECMO runs.
Results
There were 4730 CDH-infants examined. The largest association with long ECMO runs was on-ECMO repair (OR: 3.72, 95% CI: 3.013–4.602, p