Predictive factors for the development of postoperative Hirschsprung-associated enterocolitis in children operated during infancy
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In brief
In brief
Retrospective study of 35 infants with Hirschsprung disease identifies long-segment disease and older age at definitive surgery as significant risk factors for postoperative enterocolitis. Patients with Trisomy 21 who developed HAEC required longer hospitalizations, highlighting the need for early surgical intervention in high-risk populations.
Written by the GCMD Library team from the article.
Abstract
Purpose
The risk factors for postoperative Hirschsprung-associated enterocolitis (HAEC) are still incompletely understood, especially age at which surgery is performed. Therefore, the aim of this study was to identify the risk factors for the development of postoperative HAEC in children operated during infancy.
Methods
Thirty-five children who had undergone radical surgery for Hirschsprung disease (HD) during infancy were included in the study. They were divided into two groups; those who developed postoperative HAEC (HAEC, 14 patients) and those who did not (no HAEC, 21 patients). Their medical records were retrospectively reviewed for clinical details.
Results
Developing postoperative HAEC was significantly associated with long-segment HD (p = 0.020) and the age at radical surgery (p = 0.0241). No other factors had a significant association with postoperative HAEC. In the patients who developed postoperative HAEC (n = 14), those with Trisomy 21 had significantly longer hospitalizations than those without. Patients with long-segment HD had a higher hospitalization rate than those with short-segment HD.
Conclusion
This study clearly showed that long-segment HD and older age at radical surgery are risk factors for developing postoperative HAEC.