Polyp Progression in Paediatric Patients with Familial Adenomatous Polyposis - A Single Centre Experience
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Oct 2020 · 1 min read
In brief
In brief
Single-center retrospective study examining adenoma progression in 84 pediatric FAP patients undergoing colonoscopy surveillance. Analysis evaluates natural history of polyp development and factors influencing optimal timing for prophylactic colectomy in children with familial adenomatous polyposis.
Written by the GCMD Library team from the article.
Objectives: Prophylactic colectomy at a premalignant stage is the cornerstone of management of familial adenomatous polyposis (FAP). Prior to surgery, colonoscopy surveillance is recommended in children with FAP. This study aimed to examine the natural history of FAP in children by evaluating adenoma progression and factors influencing timing of colectomy. Method: Patients with FAP under the age of 18 years at first surveillance colonoscopy and who had undergone more than one colonoscopy were identified. Demographic, endoscopic, genetic and surgical data were retrieved. Cumulative adenoma (polyp) counts were obtained whilst accounting for any polypectomies during the study period. The rate of polyp progression and factors influencing the timing of colectomy.were evaluated. Results: Eighty-four patients (50% male; mean age at first colonoscopy 13 years [SD 1.97]) were identified, of which 83 had a family history of FAP. At first colonoscopy, 67 (79%) had