Pneumatosis Intestinalis after Hematopoietic Stem Cell Transplantation: When Not Doing Anything is Good Enough
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In brief
In brief
Retrospective study of 990 pediatric HSCT recipients finds pneumatosis intestinalis in 5.4%, primarily in allogeneic transplant patients on steroids. Unlike necrotizing enterocolitis, PI in this population rarely requires intervention—81% resolved with observation alone in median 15 days, even when pneumoperitoneum present.
Written by the GCMD Library team from the article.
Abstract
Background/Purpose
Pneumatosis intestinalis (PI) has been reported in hematopoietic stem cell transplant recipients (HSCT) since 1980s and at present there is no uniform consensus of the significance and management of this condition.
Methods
We retrospectively reviewed medical records of 990 consecutive pediatric HSCT recipients and examined data for clinical PI presentation, management and outcomes
Results
PI was identified in 53 patients (5.4%), mainly allogeneic HSCT recipients receiving systemic steroids. Abdominal X-ray was the main diagnostic modality. Forty-seven patients (89%) were evaluated because of clinical concerns and others were identified as incidental findings. Pneumoperitoneum was reported in 15 patients (28%). None of these patients had signs of acute abdomen. The majority of patients (43/53, 81%) had no targeted clinical intervention for PI and resolved PI in a median of 15 days (IQR 3–61). Surgery consult was only requested for 7/53 (13%) patients, three of whom had evidence of pneumoperitoneum. None of these patients required any surgical interventions.
Conclusions
Pneumatosis intestinalis commonly occurs in HSCT recipient receiving steroids, but unlike with NEC, PI rarely poses clinical risk after transplant. The majority of HSCT recipients with PI require only close monitoring without interventions. Surgical evaluation should be based on clinical symptoms and not PI presence alone.