Perioperative Transfusions and Venous Thromboembolism.
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In brief
In brief
Retrospective analysis using NSQIP pediatric data (2012-2017) examines the association between perioperative red blood cell transfusion and postoperative venous thromboembolism in children. Study employs age-stratified multivariable regression to assess VTE risk within 30 days of surgery across neonatal, infant, and older pediatric populations.
Written by the GCMD Library team from the article.
BACKGROUND AND OBJECTIVES:
Annual incidence of venous thromboembolism (VTE) including postoperative VTE in hospitalized children is rising significantly. A growing body of evidence supports the role of red blood cells (RBCs) in pathologic thrombosis. In this study, we examined the association of perioperative RBC transfusion with postoperative VTE in pediatric patients.
METHODS:
The pediatric databases of the American College of Surgeons' National Surgical Quality Improvement Project from 2012 to 2017 were used. Multivariable logistic regression was used to examine the association between perioperative RBC transfusion status and the development of new or progressive VTE within 30 days of surgery. The analyses were age stratified, as follows: neonates (≤28 days), infants (>28 days and