Percutaneous core needle biopsy of neuroblastoma in the pediatric population: what have we learned in the last decade
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In brief
In brief
This retrospective study of 79 pediatric neuroblastoma patients demonstrates that image-guided core needle biopsy achieves 91% diagnostic adequacy with a safety profile comparable to surgical open biopsy. The findings support CNB as the preferred first-line approach for tissue diagnosis in neuroblastoma when technically feasible.
- Core needle biopsy achieved 91% adequacy rate for neuroblastoma diagnosis, comparable to surgical biopsy with similar safety profile
- CNB should be considered first-line for neuroblastoma tissue diagnosis when feasible, replacing traditional open surgical biopsy
- Image-guided CNB provides sufficient tissue for histopathological analysis while avoiding surgical morbidity in pediatric patients
- Only 3 of 35 patients required repeat biopsy after initial CNB, demonstrating high first-pass success rate
- Ten-year retrospective data supports CNB as safe alternative across all tumor stages and locations in pediatric neuroblastoma
Written by the GCMD Library team from the article.
Abstract
Introduction
Historically, neuroblastoma has been diagnosed by surgical open biopsy (SB). In recent decades, core needle biopsy (CNB) has replaced surgical biopsy due to its safe and adequate method of obtaining tissue diagnosis.
Aim
Our study aimed to assess the effectiveness of CNB in obtaining tissue diagnosis for neuroblastoma and evaluate its safety profile in terms of post-operative complications, in comparison to SB.
Methods
A retrospective cohort study, including all patients younger than 18 years who were diagnosed with neuroblastoma from 2012 until 2022 in a single tertiary medical center. Patients’ demographics, tumor size and location, pathological results, and clinical outcomes were collected.
Results
79 patients were included in our study: 35 biopsies were obtained using image-guided CNB and 44 using SB. Patients’ and tumor characteristics including age, gender, tumor volume, and stage were similar in both groups. The biopsy adequacy rate in the CNB group was 91% and 3 patients in this group underwent repeated biopsy. The safety profile in the CNB group was similar to the SB group.
Conclusions
CNB is a safe method and should be considered the first choice for obtaining tissue diagnosis when feasible due to its high adequacy in terms of tumor histopathological features.