Pediatric gastric adenocarcinoma: A National Cancer Data Base review
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In brief
In brief
Retrospective NCDB analysis comparing gastric adenocarcinoma in pediatric versus adult patients found that children present with significantly more advanced disease, including higher rates of poorly differentiated tumors and stage 4 disease. Signet ring cell histology was more than twice as common in pediatric cases, highlighting distinct biological behavior in this rare pediatric malignancy.
Written by the GCMD Library team from the article.
Purpose
We sought to compare the presentation, management, and outcomes in gastric adenocarcinoma cancer for pediatric and adult patients.
Methods
Using the 2004 to 2014 National Cancer Database (NCDB), patients ≤21 years (pediatric) were retrospectively compared to >21 years (adult). Chi-squared tests were used to compare categorical variables, and Cox regression was used to estimate hazard ratios (HR) for survival differences.
Results
Of the 129,024 gastric adenocarcinoma cases identified, 129 (0.10%) occurred in pediatric patients. Pediatric cases presented with more advanced disease, including poorly differentiated tumors (81% vs 65%, p = 0.006) and stage 4 disease (56% vs 41%, p = 0.002). Signet ring adenocarcinoma comprised 45% of cases in the pediatric group as compared to 20% of cases in the adults (P