Passive Perinatal Immunotherapy via Transamniotic Antibody Delivery
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Read the article on jpedsurg.org ↗Article · Oct 2021 · 1 min read
In brief
In brief
This preclinical study demonstrates that therapeutic antibodies can be successfully delivered to the fetus via intra-amniotic injection, with dose-dependent distribution to neonatal serum and tissues. The research establishes proof-of-concept for transamniotic passive immunization as a potential route for perinatal therapeutic interventions.
Written by the GCMD Library team from the article.
Purpose
We sought to determine whether the amniotic cavity/fluid could be an attainable route of administration of therapeutic antibodies to the fetus/neonate.
Methods
Time-dated pregnant dams (n=9) received volume-matched intra-amniotic injections of either saline (n=29), or different concentrations of a human IgG that lacked homology with rodents: 5mg/mL (n=28); 10mg/mL (n=28); or 15mg/mL (n=24). At term, the presence of the IgG was quantified by ELISA in the serum, bone marrow, spleen, thymus, and brain of all neonates, and in the maternal serum. Statistical analysis was by median regression with significance set at Bonferroni-adjusted p