Partially Hydrolyzed Guar Gum Alleviates Small Intestinal Mucosal Damage after Massive Small Bowel Resection along with Changes in the Intestinal Microbiota
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In brief
In brief
This rat model study demonstrates that partially hydrolyzed guar gum (PHGG) supplementation reduces small intestinal mucosal damage and inflammation following massive bowel resection. PHGG administration increased beneficial Lachnospiraceae bacteria, suggesting microbiota modulation as a mechanism for intestinal protection in short bowel syndrome.
Written by the GCMD Library team from the article.
Purpose
Short bowel syndrome is associated with intestinal mucosal inflammation and microbial dysbiosis, leading to intractable complications. Partially hydrolyzed guar gum (PHGG) has trophic and anti-inflammatory effects on the intestine. We investigated whether PHGG ameliorates small intestinal mucosal damage and alters the intestinal microbiota using a rat small bowel resection (SBR) model.
Methods
Sprague Dawley rats were divided into sham operation (Sham), Sham/PHGG, SBR, and SBR/PHGG groups. On day 21, all rats were euthanized. To assess small intestinal mucosal damage, the degeneration rate was morphometrically evaluated and immunohistochemically examined using anti-CD45 antibodies. Analyses of fecal microbiota using 16S rRNA and short-chain fatty acid production were also performed.
Results
The mucosal degeneration rate was significantly higher in the SBR group than in the Sham or SBR/PHGG groups. The number of CD45-positive cells was significantly higher in the SBR group than in the Sham, Sham/PHGG, or SBR/PHGG groups. The relative abundance of family Lachnospiraceae was significantly higher in the SBR/PHGG group than in the SBR group.
Conclusions
PHGG administration alleviated small intestinal mucosal damage which could be associated with modulation of the intestinal microbiota.