From
Dr. Michael Helmrath
Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.
pubmed.ncbi.nlm.nih.gov shows its articles on its own site.
Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This study uses human iPSC-derived liver organoids to investigate how paracrine signaling influences hepatocyte maturation during organogenesis. The self-organizing model enables dissection of molecular mechanisms that drive liver development, offering insights for regenerative medicine applications.
Written by the GCMD Library team from the article.
A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis. Previous animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact regulate hepatocyte differentiation. To dissect the relative contributions of the paracrine effects, we first established a liver organoid using human induced pluripotent stem cells (iP…
Statements in this article
A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis.
Simultaneous paracrine signaling and cell-to-cell surface contact regulate hepatocyte differentiation.
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