Pancreatic islet cell tumors in adolescents and young adults
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Read the article on jpedsurg.org ↗Article · Apr 2019 · 1 min read
In brief
In brief
This NCDB study examines pancreatic islet cell tumors in 383 adolescent and young adult patients (ages 15-39), finding that nearly half presented with early-stage disease and 70% underwent surgical resection. AYA patients demonstrated better overall survival and underwent more extensive resections compared to older adults with the same diagnosis.
Written by the GCMD Library team from the article.
Background
Pancreatic islet cell tumors are rare in adolescents, and most studies published to date focus on older patients. We utilized a national database to describe the histology and clinical pattern of pancreatic islet cell tumors in adolescent and young adult (AYA) patients, and to compare AYAs to older adults. We hypothesized that AYAs with pancreatic islet cell tumors would have better overall survival.
Methods
The National Cancer Data Base (NCDB, 1998–2012) was queried for AYA patients (15–39 years) with a pancreatic islet cell tumor diagnosis. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted and compared to adults (≥40 years).
Results
383 patients (56.4% female, 65% non-Hispanic Whites) were identified, with a median age of 27 (IQR 16–34) years. Islet cell carcinoma was the most common histology. Of patients with known stage of disease, 49% presented with early stage (I or II). Seventy percent of patients underwent surgical resection, including local excision 44%, Whipple procedure 37.5%, or total pancreatectomy 19%. Chemotherapy was utilized in 27% and radiotherapy in 7%. All-cause mortality was 36%. AYA patients underwent more extensive resections (p = 0.001) and had lower mortality rates (p