Overfeeding-associated hyperglycemia and injury-response homeostasis in critically ill neonates
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Read the article on jpedsurg.org ↗Article · Mar 2018 · 1 min read
In brief
In brief
Study of critically ill premature infants demonstrates that excessive caloric delivery during high metabolic stress states (CRP ≥50mg/L) significantly increases hyperglycemia risk. Findings suggest caloric intake should be titrated to injury severity to maintain metabolic homeostasis in acutely ill neonates.
Written by the GCMD Library team from the article.
Background
Injury severity induces a proportionate acute metabolic stress response, associated with increased risk of hyperglycemia. We hypothesized that excess caloric delivery (overfeeding) during high stress states would increase hyperglycemia and disrupt response homeostasis.
Methods
Gestational age, daily weight, total daily caloric intake, serum C-reactive protein (CRP), prealbumin, and blood glucose concentrations in all acutely-injured premature NICU infants requiring TPN over the past 3years were reviewed. Injury severity was based on CRP and patients were divided into high (CRP ≥50mg/L) versus low (CRP f)=0.0353). When high stress patients were separated into high caloric intake (≥70kg/kcal/day) versus low caloric intake (