Outcomes in the giant omphalocele population: A single center comprehensive experience
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In brief
In brief
Single-center retrospective study of 35 giant omphalocele patients examining outcomes based on closure technique and associated anomalies. Unfavorable outcomes correlated with major congenital and cardiac anomalies and sac rupture, while higher gestational age and birth weight were protective factors.
Written by the GCMD Library team from the article.
Background/Purpose
Morbidity and mortality in the giant omphalocele population is complicated by large abdominal wall defects, physiologic aberrancies, and congenital anomalies.
We hypothesized different anomalies and treatment types would affect outcomes.
Methods
A 2009–2018 retrospective chart review of giant omphaloceles was performed.
Exclusions included cloacal exstrophy, transfer after 3 weeks, surgery prior to transfer, conjoined twins, or not yet achieving fascial closure. Thirty-five patients met criteria and mortality and operative morbidity categorized them into favorable (n = 20) or unfavorable (n = 15) outcomes. Odds ratios analyzed potential predictors. Survivors were stratified into staged (n = 11), delayed (n = 8), and primary closure (n = 6) for subgroup analysis.
Results
Unfavorable outcomes were associated with other major congenital anomalies, sac rupture, and major cardiac anomalies, but had significantly lower odds with increasing gestational age (p = 0.03) and birth weight (p