Outcomes Analyses of Pediatric Acute Liver Failure Subjects Listed for Liver Transplantation
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Jun 2022 · 1 min read
In brief
In brief
This SRTR database analysis of 397 pediatric acute liver failure patients listed for transplant (2002-2015) reveals significantly worse waitlist and post-transplant survival compared to non-PALF patients, with two-thirds having indeterminate etiology. Living-donor transplants showed equivalent outcomes to deceased-donor transplants despite the urgency of PALF cases.
Written by the GCMD Library team from the article.
Background: We characterized recent outcomes in US pediatric acute liver failure (PALF) subjects listed for liver transplantation (LT) using the Scientific Registry of Transplant Recipients (SRTR) database.
Methods: Pediatric subjects listed for LT from 2002 to 2015 were assigned to the "PALF" group based on status 1/1A listing, INR >2, no hepatic artery thrombosis, and no primary graft nonfunction (N = 397). Subjects were assigned to the "non-PALF" group if listed with any status other than 1/1A (N = 4509).
Results: The PALF group had more infants <3 months of age and males at listing for LT compared to the non-PALF group. Two-thirds of PALF subjects had an indeterminate etiology. LT waitlist survival was significantly worse in the PALF group compared to the non-PALF group. Likelihood of removal from the LT waitlist for being "too sick" was higher, while that of removal for "spontaneous recovery" was lower in PALF subjects. Post-LT short-term (30 days) and long-term (60 months) outcomes were also significantly worse in PALF versus non-PALF subjects. PALF subjects who underwent living-donor-liver-transplant (LDLT) had similar LT waitlist times and post-LT survival compared to those undergoing deceased-donor-liver-transplant (DDLT). Over the study period, we observed a decreased number of liver transplants, and increase in LT waitlist- and short-term post-LT-survival in PALF subjects.
Conclusion: LT waitlist and post-LT outcomes are worse in PALF subjects compared to non-PALF subjects. PALF subjects who undergo LDLT have similar waitlist times and post-LT outcomes compared to those undergoing DDLT.
DOI: 10.1097/MPG.0000000000003448