Optimization of In-Continuity Spring-Mediated Intestinal Lengthening
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Read the article on jpedsurg.org ↗Article · Oct 2019 · 1 min read
In brief
In brief
Experimental study in juvenile pigs evaluating spring-mediated intestinal lengthening techniques to treat short bowel syndrome. Researchers found that 50% intestinal plication achieved 2.7-fold length increase compared to 1.3-fold with 10% plication, and tested dissolvable sutures for spontaneous spring passage.
Written by the GCMD Library team from the article.
Background
Spring-mediated intestinal lengthening has been studied in numerous animal models to effectively achieve up to a 3-fold increase in length. In this study we are interested in optimizing this method of spring lengthening.
Methods
Juvenile mini-Yucatan pigs underwent laparotomy for spring implantation. Springs were secured by plicating the intestine around the springs. In one set of experiments, varying degrees of plication were compared to determine the necessary narrowing needed to confine the spring. In another set of experiments, dissolvable sutures were used for the plication to allow for spontaneous spring passage postoperatively. Intestinal segments were retrieved and evaluated for lengthening and histological changes.
Results
Pigs tolerated their diet advancement to a regular diet postoperatively. 10% plication resulted in a 1.3-fold increase in length, while 50% plication resulted in a 2.7-fold increase in length (p