Opportunities for novel diagnostic and cell-based therapies for Hirschsprung disease
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Read the article on jpedsurg.org ↗Article · Nov 2021 · 1 min read
In brief
In brief
This review examines emerging diagnostic imaging techniques for visualizing the enteric nervous system and novel cell-based therapies using neuronal stem cells to replace missing enteric neurons in Hirschsprung disease. These advances offer potential solutions for improving early diagnosis and addressing long-term complications including fecal incontinence, constipation, and HAEC.
Written by the GCMD Library team from the article.
Despite significant progress in our understanding of the etiology and pathophysiology of Hirschsprung disease (HSCR), early and accurate diagnosis and operative management can be challenging. Moreover, long-term morbidity following surgery, including fecal incontinence, constipation, and Hirschsprung-associated enterocolitis (HAEC), remains problematic. Recent advances applying state-of-the art imaging for visualization of the enteric nervous system and utilizing neuronal stem cells to replace the missing enteric neurons and glial cells offer the possibility of a promising new future for patients with HSCR. In this review, we summarize recent research advances that may one day offer novel approaches for the diagnosis and management of this disease.