Omega-3 fatty acids are protective in hepatic ischemia reperfusion injury in the absence of GPR120 signaling
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Read the article on jpedsurg.org ↗Article · Apr 2019 · 1 min read
In brief
In brief
This experimental study demonstrates that intravenous fish oil administration protects against hepatic ischemia reperfusion injury in mice, reducing liver necrosis by 26-37% regardless of GPR120 receptor presence. The findings suggest omega-3 fatty acids confer hepatoprotection through GPR120-independent mechanisms, with implications for liver transplantation and hepatic surgery protocols.
Written by the GCMD Library team from the article.
Background
A single dose of IV fish oil (FO) before hepatic ischemia reperfusion injury (HIRI) increases hepatocyte proliferation and reduces necrosis in wild type (WT) mice. It has been suggested that the GPR120 receptor on Kupffer cells mediates FO's ability to reduce HIRI. The purpose of this study was to determine whether GPR120 is required for FO to reduce HIRI.
Methods
Sixty-four (n = 8/group) adult male WT (C57BL/6) and GPR120 knockout (KO) mice received IV FO (1 g/kg) or saline 1 h prior to HIRI or sham operation. Mice were euthanized 24 h postoperatively for analysis of hepatic histology, NFκB activity, and serum alanine transaminase (ALT) levels.
Results
FO pretreated livers had less necrosis after HIRI than saline pretreated livers in both WT (mean ± SEM 25.9 ± 7.3% less, P = 0.007) and KO (36.6 ± 7.3% less, P