From
Dr. Michael Helmrath
Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids.
pubmed.ncbi.nlm.nih.gov shows its articles on its own site.
Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This study demonstrates that nonadhesive alginate hydrogels can successfully support the growth and differentiation of human intestinal organoids derived from pluripotent stem cells, offering a defined synthetic alternative to tumor-derived matrices. The approach addresses key limitations in organoid culture scalability and clinical translation for drug screening and tissue engineering applications.
Written by the GCMD Library team from the article.
Human intestinal organoids (HIOs) represent a powerful system to study human development and are promising candidates for clinical translation as drug-screening tools or engineered tissue. Experimental control and clinical use of HIOs is limited by growth in expensive and poorly defined tumor-cell-derived extracellular matrices, prompting investigation of synthetic ECM-mimetics for HIO culture. Si…
Educational content from recorded physician discussions — not medical advice. Talk to your (or your child's) care team about your situation.
Article
Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site.
Michael Helmrath · Published Nov 2026
Article
Mechanical stimulation promotes human intestinal villus morphogenesis in vivo
Michael Helmrath · Published Nov 2026
Article
Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury.
Michael Helmrath · Published Nov 2026
Article
Drug-induced secretory diarrhea: A role for CFTR.
Michael Helmrath · Published Nov 2026
Article
Gastrointestinal organoids: a next-generation tool for modeling human development.
Michael Helmrath · Published Nov 2026
Article
Organoid Center Strategies for Accelerating Clinical Translation.
Michael Helmrath · Published Nov 2026
Article
Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection.
Michael Helmrath · Published Nov 2026
Article
Obesity in the adolescent female
Michael Helmrath · Published Nov 2026
Article
Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.
Michael Helmrath · Published Nov 2026
Article
Bariatric surgery for severely overweight adolescents: concerns and recommendations
Michael Helmrath · Published Nov 2026
Article
Predictors of Preoperative Program Non-Completion in Adolescents Referred for Bariatric Surgery.
Michael Helmrath · Published Nov 2026
Article
Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults
Michael Helmrath · Published Nov 2026