Neurodevelopmental outcomes of infants with esophageal atresia and tracheoesophageal fistula
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In brief
In brief
Single-center study examining mortality, growth, and neurodevelopmental outcomes in 253 infants with esophageal atresia and tracheoesophageal fistula over 15 years. Overall mortality was 8.3%, primarily due to cardiac malformations, with 40% of infants born preterm.
Written by the GCMD Library team from the article.
Background
Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is a complex disorder, and most outcome data are confined to mortality and feeding-related morbidities. Our objective was to examine mortality, growth and neurodevelopmental outcomes in a large recent cohort of infants with EA/TEF.
Methods
Single center study of EA/TEF infants referred from January 2000 to December 2015. Data collected included associated defects, neonatal morbidity and mortality and growth and neurodevelopmental outcomes at age 12–36months. Multiple regression analysis was used to determine variables associated with adverse outcome.
Results
Of the 253 infants identified, 102 infants (40%) were preterm. Overall mortality was 8.3%, the majority from major cardiac malformations (p