Neurodevelopmental impairment in children with congenital diaphragmatic hernia: Not an uncommon complication for survivors
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Read the article on jpedsurg.org ↗Article · Jun 2019 · 1 min read
In brief
In brief
Systematic review of 3,541 CDH patients found 23% developed neurodevelopmental impairment, with significantly higher rates in ECMO-treated survivors (49%) versus non-ECMO patients (22%). Study identifies NDI as a common complication requiring long-term surveillance and evaluates neuroimaging findings and predictive risk factors.
Written by the GCMD Library team from the article.
Purpose
To evaluate neurodevelopmental impairment (NDI) in children born with congenital diaphragmatic hernia (CDH).
Methods
Using a defined search strategy, a systematic review was conducted to define the incidence and types of NDI, to report abnormal neuroimaging findings and to evaluate possible NDI predictors. A meta-analysis was performed on comparative studies reporting risk factors for NDI, using RevMan 5.3.
Results
Of 3541 CDH children (33 studies), 829 (23%) had NDI, with a higher incidence in CDH survivors who received ECMO treatment (49%) vs. those who had no ECMO (22%; p