Necrotizing enterocolitis in term neonates: A different disease process?
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Read the article on jpedsurg.org ↗Article · Mar 2019 · 1 min read
In brief
In brief
Retrospective study comparing necrotizing enterocolitis in term versus preterm infants found distinct disease patterns. Term neonates with NEC were more likely to have undergone cardiac surgery but required less surgical intervention and had lower disease severity than preterm counterparts, suggesting different underlying pathophysiology.
Written by the GCMD Library team from the article.
Introduction
Necrotizing enterocolitis (NEC) has been a long-recognized complication of prematurity, but there is a paucity of studies on term infants. We sought to characterize the clinical presentation and outcomes of full term (FT) infants with NEC and compare these to our experience with preterm (PT) neonates.
Methods
We conducted a chart review of infants admitted to the NICU at University of Michigan with a diagnosis of NEC for over a 10-year period with a Modified Bell stage of 2 or greater. We compared the outcomes and comorbidities of PT against those of FT, defined as gestational age at birth below and above 37 weeks, respectively.
Results
Out of 170 infants, 28(17%) were FT. FT neonates were more likely to have undergone cardiac surgery for a congenital defect, excluding PDA ligation (64% vs. 8%)*. When compared to FT infants, PT infants were more likely to require surgical intervention (18% vs. 59%)*, have Bell stage 3 disease (82% vs. 43%)*, require vasopressor support (21% vs. 42%)+, and require ventilatory support (43% vs 75%)*. *p