Mid–short-term risk factors for chronic renal failure in children with posterior urethral valve
link.springer.com shows its articles on its own site.
Read the article on link.springer.com ↗Article · Sep 2022 · 1 min read
In brief
In brief
Retrospective study of 143 children with posterior urethral valve identifies delayed valve resection (>35.5 months) and elevated detrusor pressure (>41.65 cmH2O) as key predictors of chronic renal failure. Maintaining lower bladder pressures post-ablation correlates with better long-term kidney outcomes.
Written by the GCMD Library team from the article.
Abstract
Objectives
To analyze the mid–short-term risk factors for chronic renal failure (CRF) in children with posterior urethral valve (PUV) after valve ablation.
Materials and methods
A retrospective study of 143 patients with PUV who underwent operation was performed. Patients were divided into CRF group (n = 39) and non-CRF group (n = 104). Clinical data of both groups such as the first resection age, last resection age, number of operations, the maximal detrusor pressure (Pdetmax), and vesicoureteral reflux (VUR) were collected and analyzed.
Results
The first resection age, last resection age, and the Pdetmax of patients in the CRF group were higher than those of patients in the non-CRF group (P < 0.05). Multiple regression analysis showed that the indicators related to chronic renal failure were last resection age (β = 1.034, P < 0.05) and Pdetmax (β = 1.068, P < 0.05). The cut-off value of last resection age was 35.5 months, Pdetmax was 41.65 cmH2O. There was positive correlation of final blood creatinine with last resection age and Pdetmax.
Conclusion
The last resection age and Pdetmax are the risk factors of chronic renal failure in children with PUV. A Pdetmax of lower than 41.65 cmH2O indicates a good prognosis of renal function in patients with PUV.