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Microinjection With Nanoparticles to Deliver Drugs in Prenatal Lung Explants - A Pilot Study for Prenatal Therapy in Congenital Diaphragmatic Hernia
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Read the article on jpedsurg.org ↗Article · Feb 2024 · 1 min read
In brief
In brief
This pilot study explores a novel ex vivo microinjection technique using nanoparticles to deliver therapeutic agents into fetal lung tissue during tracheal occlusion procedures. The research aims to enhance outcomes for severe CDH cases beyond current FETO interventions by enabling targeted prenatal drug delivery.
Written by the GCMD Library team from the article.
Fetoscopic endoluminal tracheal occlusion (FETO) improves the survival rate in fetuses with severe congenital diaphragmatic hernia (CDH). We hypothesize that prenatal therapies into the trachea during FETO can further improve outcomes. Here, we present an ex vivo microinjection technique with rat lung explants to study prenatal therapy with nanoparticles.
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