Microbiota Dysbiosis and Gut-Brain Axis Interactions in Short Bowel Syndrome: A Rat Model Study

In brief

This preclinical study examines how extensive intestinal resection in short bowel syndrome disrupts gut microbiota balance and affects gut-brain axis signaling pathways using a rat model. Findings may inform therapeutic strategies targeting microbiome restoration and neurological complications in SBS patients.

• Short bowel syndrome disrupts gut microbiota composition following extensive intestinal resection
• SBS may alter gut-brain axis signaling pathways through microbiota dysbiosis
• Rat models provide translational insights into microbiota-GBA interactions in SBS
• Understanding microbiota changes in SBS could inform probiotic or dietary interventions
• GBA biomarkers may serve as targets for monitoring or treating SBS complications

Written by the GCMD Library team from the article.