Megameatus intact prepuce: a systematic review of surgical techniques and long-term outcomes
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Read the article on link.springer.com ↗Article · Dec 2024 · 1 min read
In brief
In brief
This systematic review analyzes surgical management of megameatus intact prepuce (MIP), a rare hypospadias variant with diverse phenotypes. Reviewing 18 studies encompassing 524 patients, the analysis examines surgical techniques including preputial reconstruction, urethroplasty, and meatal advancement with success rates of 77-100%, while highlighting gaps in long-term functional and cosmetic outcome data.
- MIP is a rare hypospadias variant with diverse phenotypes requiring individualized surgical planning and urological evaluation.
- Surgical success rates range from 77-100% across preputial reconstruction, urethroplasty, and meatal advancement techniques.
- Long-term functional and cosmetic outcome data remain limited, highlighting need for extended follow-up studies.
- Current literature encompasses 524 patients but lacks standardized reporting of outcomes across surgical approaches.
- Genetic and environmental factors underlying MIP phenotypic variability require further investigation.
Written by the GCMD Library team from the article.
Abstract
Megameatus intact prepuce (MIP) presents with diverse phenotypes that complicate the management of this rare but complex hypospadias variant. Current data on optimal treatment methods and patient outcomes are sparse, unintegrated, and therefore challenging to implement clinically. A comprehensive systematic review of the existing literature on MIP was conducted according to PRISMA guidelines. Electronic databases including PubMed, Embase, and Scopus were searched for relevant articles published up to [2024]. Key aims were to assess the safety and efficacy of different surgical interventions, and synthesize corresponding outcomes reported in the literature. The search yielded 18 articles meeting the inclusion criteria, representing a total of 524 enrolled patients across multiple geographic regions. Diagnosis of MIP typically involves clinical examination, imaging studies, and urological evaluation. Surgical management options included preputial reconstruction, urethroplasty, and meatal advancement with glanuloplasty. Reported outcomes varied, with success rates ranging from [77.1–100%]. Long-term follow-up data on functional and cosmetic outcomes were limited. Megameatus intact prepuce presents diagnostic and management challenges due to low prevalence and variable presentation. This systematic review presents a current understanding of MIP diagnosis, surgical techniques, and patient outcomes. Future studies should assess the long-term functional outcomes of different surgical approaches, and investigate the underlying genetic and environmental factors contributing to the diverse clinical manifestations of MIP.