Long-Term Outcomes and Disease Burden of Neonatal Onset Short Bowel Syndrome
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Read the article on jpedsurg.org ↗Article · Nov 2019 · 1 min read
In brief
In brief
Long-term follow-up of 70 adolescents with neonatal-onset short bowel syndrome shows excellent survival (0% mortality) and 94% transplant-free outcomes, with 76% achieving enteral autonomy. Patients weaned from parenteral nutrition as late as 10 years post-diagnosis, though those remaining PN-dependent experienced higher hospitalization burden.
Written by the GCMD Library team from the article.
Purpose
The study aims to describe long-term outcomes and disease burden of neonatal onset short bowel syndrome (SBS).
Methods
Utilizing the WHO criteria for adolescence, patients 10–19 years of age with neonatal onset SBS requiring parenteral nutrition (PN) for >90 days and followed by our multidisciplinary intestinal rehabilitation center between 2009 and 2018 were included for analysis.
Results
Seventy adolescents with SBS were studied. Median (IQR) age at last follow up in our center was 15 (11, 17) years. There was 0% mortality in the cohort, and 94% remained transplant free. Fifty-three patients (76%) achieved enteral autonomy. Three patients were weaned from PN without transplantation after six years of follow-up and another four after ten years of care at our multidisciplinary center. Disease burden remained higher in adolescents receiving PN, including inpatient hospitalizations (p