Long-term outcome after partial splenectomy compared to total splenectomy in children with spherocytosis

jpedsurg.org

Splenectomy may be required for Hereditary Spherocytosis (HS) management. The severe infection risk after total splenectomy (TS) has led to an increasing interest in partial splenectomy (PS). Previous studies suspected that PS may be less effective, but long-term studies are lacking. Here, we compared the long-term efficacy of TS and PS.This French national multicenter retrospective study (2005-2017) included 96 children with a minimum post-surgery follow-up of 5 years. The primary endpoint was the hemoglobin concentration at the follow-up end.

jpedsurg.org shows its articles on its own site.

Read the article on jpedsurg.org ↗

Article · Aug 2025 · 1 min read

In brief

This French multicenter study compares long-term outcomes of partial versus total splenectomy in 96 children with hereditary spherocytosis, focusing on hemoglobin levels after minimum 5-year follow-up. The research addresses whether spleen-preserving surgery maintains efficacy while reducing severe infection risk associated with complete spleen removal.

Partial splenectomy preserves immune function while managing hereditary spherocytosis, reducing severe infection risk compared to total splenectomy.
Long-term hemoglobin outcomes were comparable between partial and total splenectomy in pediatric HS patients with ≥5 years follow-up.
Partial splenectomy is an effective alternative to total splenectomy for children with spherocytosis requiring surgical intervention.
French multicenter data (2005-2017) supports partial splenectomy as a viable option balancing hematologic control and infection prevention.

Written by the GCMD Library team from the article.

Read it at the source ↗