Long-term assessment of bilirubin and transaminase trends in pediatric intestinal failure patients during the era of hepatoprotective parenteral nutrition
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In brief
In brief
Retrospective cohort study examining long-term liver function in pediatric intestinal failure patients receiving hepatoprotective parenteral nutrition (soy-based lipids <2.5g/kg/day) from 2012-2019. Analysis stratifies patients by nutritional autonomy status to assess relationship between PN dependence and serum liver markers over time.
Written by the GCMD Library team from the article.
Type of Study
: Retrospective Cohort
Level of Evidence
: III
Purpose
: This study aimed to characterize the relationship between hepatoprotective parenteral nutrition (PN) dependence and long-term serum liver tests in children with intestinal failure (IF).
Methods
: A retrospective review was performed of children with severe IF (>90 consecutive days of PN) who were followed from 2012-2019 at a multidisciplinary intestinal rehabilitation program. Patients were stratified into three groups based on level of PN dependence at most recent follow up: EN (achieved enteral autonomy), mixed (parenteral and enteral nutrition), and PN (>75% of caloric intake from PN). PN at any point for this cohort was hepatoprotective, defined as soy-based lipids