Liver histopathology in patients with hepatic masses and the Abernethy malformation
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Read the article on jpedsurg.org ↗Article · Dec 2018 · 1 min read
In brief
In brief
This retrospective study examines liver biopsy findings in pediatric patients with Abernethy malformation, a rare congenital condition where splanchnic blood bypasses the liver. Researchers compared histologic features between patients with and without coexistent hepatic masses to characterize the pathologic spectrum of this vascular anomaly.
Written by the GCMD Library team from the article.
Background/Purpose
The Abernethy malformation (AM) is a congenital venous malformation in which the splanchnic venous return bypasses the liver and drains directly into the systemic circulation. This deprives the liver of hepatotrophic growth factors and allows metabolic products of digestion to enter the systemic veins without the benefit of passing through the liver. The histologic features of liver biopsies in children with an AM were reviewed.
Methods
A retrospective review of liver biopsies in patients with AM between 1997 and 2017 was performed. Patients were divided into two groups for comparison of histologic features: presence (M+) or absence (M−) of a coexistent liver mass on imaging. Biopsies were reviewed by a pediatric pathologist. Chi-square test was used for statistical analysis between groups. Significance was assigned to p values