Is neurodevelopment impaired in Brazilian children with intestinal failure on prolonged parenteral nutrition? A single center study
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In brief
In brief
This Brazilian study evaluated neurodevelopmental outcomes in 24 children with intestinal failure receiving prolonged parenteral nutrition, finding developmental delays in approximately one-third across cognitive, motor, and language domains using Bayley III assessment. The findings highlight the need for neurodevelopmental monitoring in pediatric intestinal rehabilitation programs.
- One-third of children with intestinal failure on prolonged parenteral nutrition showed neurodevelopmental delays across cognitive, motor, and language domains.
- Developmental impairment occurred independently of hospitalization length, prematurity, or number of surgical procedures with anesthesia.
- Bayley III assessment identified delays in 34% (cognitive), 33% (motor), and 27% (language) of pediatric IF patients under 42 months.
- Multidisciplinary intestinal rehabilitation programs should incorporate routine neurodevelopmental screening for children on long-term PN.
- Neurodevelopmental monitoring is critical for pediatric IF patients, as approximately one-third demonstrate significant delays despite nutritional support.
Written by the GCMD Library team from the article.
Abstract
Purpose
To assess the neurodevelopment outcomes of children younger than 42 months of age with intestinal failure (IF) using prolonged parenteral nutrition (PN) followed by a Pediatric Multidisciplinary Intestinal Rehabilitation Program from a public tertiary hospital in Brazil.
Methods
Bayley III scale was administered in children aged 2 to 42 months with IF and receiving PN for more than 60 days. Composite scores in cognitive, motor, and language domains were analyzed. Developmental delay was defined as a performance 2 standard deviations (SD) below the average at the 3 domains. Association between Bayley III composite scores and clinical variables related to IF were tested.
Results
Twenty-four children with median (IQR) age of 17.5 months (9–28.5) were studied, 58.3% were male. Developmental delay was found in 34%, 33% and 27% of the patients in cognitive, motor, and language domains, respectively. There was no significant association between the Bayley-III composite scores and length of hospitalization, prematurity, and number of surgical procedures with anesthesia.
Conclusion
The study demonstrated impairments in the cognitive, motor and language domains in approximately one-third of young patients with IF on prolonged PN.