Insights into the etiology and embryology of gastroschisis
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In brief
In brief
This review challenges traditional theories of gastroschisis pathogenesis, proposing it results from rupture of the physiological umbilical hernia rather than a separate developmental anomaly. The article examines historical assumptions about abdominal wall defects and discusses how mesenteric injury contributes to bowel complications in affected infants.
Written by the GCMD Library team from the article.
Publication date: October 2018
Source: Seminars in Pediatric Surgery, Volume 27, Issue 5
Author(s): Sylvie Beaudoin
Abstract
The development of gastroschisis has long remained an area of interest and controversy. Successive theories about its pathogenesis are herein reviewed and discussed. Two historical assumptions, that omphalocele results from a persistent umbilical hernia, and that gastroschisis does not involve the umbilical cord, are dismissed. Therefore, one can envision gastroschisis for what it is, i.e. a ruptured physiological hernia. The causal agents for this intrauterine accident to occur are yet to be determined. Further bowel damage and complications can be explained by the mesenteric insult.