Insights into Embryology and Development of Omphalocele
sciencedirect.com shows its articles on its own site.
Read the article on sciencedirect.com ↗Article · Apr 2019 · 1 min read
In brief
In brief
This review examines the embryological mechanisms underlying omphalocele development, a common congenital abdominal wall defect occurring in approximately 1 in 2000 live births. The authors explore theories of abnormal ventral abdominal wall formation and distinguish omphalocele from gastroschisis.
Written by the GCMD Library team from the article.
Publication date: Available online 6 April 2019
Source: Seminars in Pediatric Surgery
Author(s): Faraz A. Khan, Asra Hashmi, Saleem Islam
Abstract
Congenital abdominal wall defects are one of the most common human birth defects with an incidence of about 1 in 2000 live births. While often discussed together abdominal wall defects consist mainly of two distinct entities namely gastroschisis and omphalocele. There is no clear consensus explaining the precise embryological mechanisms leading to the development of an omphalocele. Many clinicians and embryologists have attempted to explain congenital malformation as a result of failure of progression of normal embryonic development. This review summarizes the mechanisms involved in normal and abnormal development of the ventral abdominal wall.