Influence of symptom duration and WBC profile on the negative predictive value of a nondiagnostic ultrasound in children with suspected appendicitis
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In brief
In brief
Retrospective study of 2,277 pediatric patients evaluates how symptom duration and WBC profiles improve the negative predictive value of nondiagnostic ultrasounds in suspected appendicitis. Findings show NPV increases from 83.7% at ≤24 hours to 94.5% at >72 hours, with normal WBC profiles further enhancing diagnostic confidence.
Written by the GCMD Library team from the article.
Background
The aim of this study was to explore the combined negative predictive value (NPV) of symptom duration and WBC profile in children with a nondiagnostic ultrasound (US) for appendicitis.
Methods
This was a retrospective analysis of children with suspected appendicitis at a single children's hospital from 1/2010 to 3/2018. NPVs based on WBC profile and symptom duration at presentation were calculated individually and combined for children with a nondiagnostic US.
Results
2277 patients were included, of which 1018 (44.7%) had a nondiagnostic US. The NPV of a nondiagnostic US ranged from 83.7% with ≤24 h of symptoms to 94.5% with >72 h of symptoms (p