Increased risk of atopic diseases in boys with meatal stenosis: a possible pathophysiological relation
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In brief
In brief
Retrospective study of 427 boys found significantly higher prevalence of atopic conditions (atopic dermatitis, allergic rhinitis, asthma, food allergies) in patients with meatal stenosis (61%) versus controls (13%), suggesting a potential pathophysiological link between systemic atopy and urethral meatal narrowing in pediatric males.
Written by the GCMD Library team from the article.
Purpose
To evaluate the role of atopy (i.e. atopic dermatitis, allergic rhinitis, asthma, and food allergies) and its consequences on developing meatal stenosis in boys.
Methods
After obtaining ethics approval from institutional review board, a retrospective chart review was conducted to gather records of patients with meatal stenosis (Group A) presented to our pediatric urology center between August 2012 and May 2016. History of any allergic reactions including allergic rhinitis, asthma, skin, food and drug allergies was considered as positive history of atopy. A control group of children referring to our center due to other etiologies were considered as control group (Group B). Data were analyzed using student t-test and Chi-square test.
Results
During the study period, a total of 206 boys (mean age 41.01 months) were assigned to group A and 221 (mean age 35.56 months) to group B. 126 (61.16%) boys had history of allergic reactions in group A compared to 29 (13.12%) in the control arm (group B). Patients with meatal stenosis have a significantly higher (P-value