Incidence of necrotising enterocolitis before and after introducing routine prophylactic Lactobacillus and Bifidobacterium probiotics
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In brief
In brief
Retrospective 10-year study at a UK Level 3 NICU comparing necrotizing enterocolitis rates, late-onset sepsis, and mortality in high-risk preterm neonates before and after routine multistrain probiotic prophylaxis with Lactobacillus and Bifidobacterium strains.
Written by the GCMD Library team from the article.
Objective: To compare rates of necrotising enterocolitis (NEC), late-onset sepsis, and mortality in 5-year epochs before and after implementation of routine daily multistrain probiotics administration in high-risk neonates.
Design: Single-centre retrospective observational study over the 10-year period from 1 January 2008 to 31 December 2017.
Setting: Level 3 neonatal intensive care unit (NICU) of the Norfolk and Norwich University Hospital, UK.
Patients: Preterm neonates at high risk of NEC: admitted to NICU within 3 days of birth at