Improvements in intestine transplantation
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In brief
In brief
Review of advances in pediatric intestinal transplantation for short gut syndrome, highlighting improvements in patient selection, immunosuppressive protocols, and post-transplant monitoring. Key developments include drug-sparing regimens and enhanced surveillance for post-transplant lymphoproliferative disorder (PTLD).
Written by the GCMD Library team from the article.
Publication date: August 2018
Source: Seminars in Pediatric Surgery, Volume 27, Issue 4
Author(s): Neslihan Celik, Kaitlin Stanley, Jeff Rudolph, Feras Al-Issa, Beverly Kosmach, Chethan Ashokkumar, Qing Sun, Renee Brown-Bakewell, Dale Zecca, Kyle Soltys, Ajai Khanna, Geoffrey Bond, Armando Ganoza, George Mazariegos, Rakesh Sindhi
Abstract
Transplantation of the intestine in children has presented significant challenges even as it has become a standard to treat nutritional failure due to short gut syndrome. These challenges have been addressed in part by significant improvements in short and long-term care. Noteworthy enhancements include reduced need for intestine transplantation, drug-sparing immunosuppressive regimens, immune monitoring, and improved surveillance and management of PTLD and non-adherence.