Hyperacidity, overfeeding, prostaglandins, and pyloric stenosis of infancy

The real pathogenesis of Pyloric Stenosis of Infancy (PS) is becoming clearer: [1] Inherited hyperacidity starts the process, [2] Acid stimulated sphincter contraction follows, [3-5] Repeated contraction by attracting growth factors locally causes sphincter hypertrophy, especially marked in the trophic ambience of the temporarily hypergastrinaemic baby [6] [7]. It can be no coincidence that peak acidity occurs in all normal babies at around 3–4 weeks of age, the classical time that symptoms develop [8].