Histological features of complete tracheal rings in congenital tracheal stenosis
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In brief
In brief
This histological study of 31 infants with congenital tracheal stenosis found no significant differences in cartilage cell density or thickness between complete tracheal rings and normal tracheal cartilage, challenging the hypothesis that cartilage malformation causes the condition. The only notable finding was higher cell density on the ventral versus dorsal side of affected cartilage.
Written by the GCMD Library team from the article.
Abstract
Purpose
Congenital tracheal stenosis is a disease in which complete tracheal cartilage rings (CTCR) cause airway narrowing. Although tracheal cartilage malformation has been suggested as a cause of CTCR, no histological studies have been performed. Here, we report a comparison of the tissues from CTCR and normal tracheal cartilage.
Methods
Thirty-one infants who underwent slide tracheoplasty at our institution from May 2016 to August 2019 were included. Tissues from ten autopsy cases without tracheal lesions were used as controls. The survey items were tracheal cartilage cell density, cartilage thickness, and chondrocyte findings.
Results
The median cartilage cell density from cases was 23/125 × 125 µm2 and from controls was 23.5/125 × 125 µm2 (p = 0.90). The median cartilage thickness from cases was 689 µm and from controls was 840 µm (p = 0.11). Comparing the ventral and dorsal sides of the CTCR tissues, the cell density was significantly different (median ventral 23/125 × 125 µm2; median dorsal 19.5/125 × 125 µm2; p = 0.034). There were no significant findings in the chondrocytes of the CTCR tissues.
Conclusion
CTCR tissues did not differ in cartilage density and thickness from normal tracheal cartilage.