Article1 min read·Published May 2015Older

High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery

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pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Background & Aims: Little is known about the prevalence of nonalcoholic fatty liver disease (NAFLD) among severely obese adolescents or factors that determine its development. We investigated the prevalence of NAFLD in a multicenter cohort of adolescents undergoing bariatric surgery and the factors associated with it. Methods: We enrolled 242 adolescents undergoing bariatric surgery between March 2007 and February 2012 at 5 tertiary care centers into a multicenter, prospective observational cohort study. Intraoperative core liver biopsies were collected from 165 subjects; 17 were excluded because of insufficient liver tissue or use of hepatotoxic medications, so 148 remained in the study (mean age, 16.8 ± 1.6 years; median body mass index = 52 kg/m(2)). Liver tissues were analyzed by histology using validated criteria. Hepatic gene expression was analyzed in 67 samples. Results: NAFLD was present in 59% of this predominantly female (72%), white (68%), non-Hispanic (91%) cohort. Of subjects with NAFLD, 24% had borderline and 10% had definite nonalcoholic steatohepatitis (NASH). Mild fibrosis (stage 2 or lower) was observed in 18% of liver biopsies and stage 3 was observed in 0.7%, but cirrhosis was not detected. Dyslipidemia was present in 78% of subjects, hypertension in 44%, and diabetes in 14%. More severe NAFLD was associated with increasing levels of alanine aminotransferase, fasting glucose level, hypertension (each P < .01), and white blood cell count (P = .04). Only di

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Article · May 2015 · 1 min read

In brief

This multicenter study of 148 adolescents undergoing bariatric surgery found 59% had nonalcoholic fatty liver disease, with 10% showing definite NASH and 18% having mild fibrosis. More severe liver disease correlated with elevated ALT, fasting glucose, hypertension, and white blood cell count in this predominantly female cohort.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

NAFLD was present in 59% of adolescents undergoing bariatric surgery in this cohort.
ResearchResults
Of subjects with NAFLD, 24% had borderline nonalcoholic steatohepatitis (NASH) and 10% had definite NASH.
ResearchResults
Mild fibrosis (stage 2 or lower) was observed in 18% of liver biopsies and stage 3 fibrosis in 0.7%, but cirrhosis was not detected.
ResearchResults
Dyslipidemia was present in 78% of subjects, hypertension in 44%, and diabetes in 14%.
ResearchResults
More severe NAFLD was associated with increasing levels of alanine aminotransferase, fasting glucose level, hypertension (each P < .01), and white blood cell count (P = .04).
ResearchResults
The study cohort was predominantly female (72%), white (68%), and non-Hispanic (91%) with a mean age of 16.8 ± 1.6 years and median body mass index of 52 kg/m².
ResearchResults
Intraoperative core liver biopsies were collected from 165 subjects, with 17 excluded because of insufficient liver tissue or use of hepatotoxic medications.
ResearchMethods