Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma
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In brief
In brief
Retrospective study of 55 neonates with sacrococcygeal teratoma examining alpha-fetoprotein half-life kinetics post-resection. Found AFP half-life correlates with patient age (T1/2 = 0.0597 × days + 6.1643), providing baseline data for postoperative surveillance and early detection of recurrence in this patient population.
Written by the GCMD Library team from the article.
Background
Alpha-fetoprotein (AFP) is useful as a tumor marker for sacrococcygeal teratoma (SCT). We investigated the half-life of AFP in SCT.
Methods
Neonates who underwent surgical treatment for SCT between 1997 and 2016 were included in the study, whereas patients who died before or after surgery or had malignant germ cell tumors were excluded.
Results
Fifty-five non-recurrent SCT patients (M:F = 18:37) were enrolled. They underwent surgery on average 7.4 ± 4.1 days after birth. Serum AFP was measured an average 4.25 ± 2.07 times per patient. We obtained 165 half-lives following the formula (M = Mo * (1/2) Δt/T). A positive correlation was observed between half-life and patient age using the formula T1/2 = 0.0597 × days +6.1643 (p