Growth and morbidity in infants with Congenital Diaphragmatic Hernia according to initial Lung Volume: a pilot study
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Read the article on jpedsurg.org ↗Article · Jul 2021 · 1 min read
In brief
In brief
Pilot study examining whether early lung volume measurements (functional residual capacity) after extubation predict growth outcomes at 12 and 24 months in CDH survivors. Addresses the poorly understood relationship between residual lung hypoplasia and failure to thrive in this population.
Written by the GCMD Library team from the article.
Background: In congenital diaphragmatic hernia (CDH) survivors, failure to thrive is a well-known complication, ascribed to several factors. The impact of lung volume on growth of CDH survivors is poorly explored. Our aim was to evaluate if, in CDH survivors, lung volume (LV) after extubation correlates with growth at 12 and 24 months of life.
Methods: LV (measured as functional residual capacity-FRC) was evaluated by multibreath washout traces with an ultrasonic flowmeter and helium gas dilution technique, shortly after extubation. All CDH survivors are enrolled in a dedicated follow-up program. For the purpose of this study, we analyzed the correlation between FRC obtained shortly after extubation and anthropometric measurements at 12 and 24 months of age. We also compared growth between infants with normal lungs and those with hypoplasic lungs according to FRC values. A p