Article1 min read·Published Sep 2005Older

Glucagon-like peptide-2 acutely increases proximal small intestinal blood flow in TPN-fed neonatal piglets

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pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Glucagon-like peptide-2 (GLP-2) is a gut hormone that is secreted in response to enteral feeding and stimulates small intestinal mucosal growth. We have previously shown that GLP-2 infusion acutely increases portal venous blood flow in TPN-fed piglets. The aim of this study was to localize the vasoactive effect of GLP-2 within the gastrointestinal tissues and other visceral organs in TPN-fed piglets. Tissue blood flow rates were quantified using fluorescent microsphere deposition in anesthetized TPN-fed piglets given intravenous infusion of GLP-2 at either 500 pmol x kg(-1) x h(-1) (low GLP-2, n = 7 pigs) or 2,000 pmol x kg(-1) x h(-1) (high GLP-2, n = 8 pigs) for 2 h. Compared with baseline, the low and the high GLP-2 treatment significantly increased the blood flow rate in the duodenum (+77%) and jejunum (+40% and 80%), respectively, but blood flow to the distal small intestine and colon (-15%) was unchanged or slightly decreased. Baseline mucosal blood flow was five-fold higher than serosal blood flow; however, high GLP-2 treatment increased serosal (+140%) to a larger degree than mucosal blood flow (+73%). The high GLP-2 dose increased pancreatic flow (+34%) but decreased blood flow in the kidneys (-14%) and stomach (-12%), whereas the spleen and brain were unaffected. These findings suggest that the acute GLP-2-mediated stimulation of portal blood flow in TPN-fed piglets occurs principally via increased blood flow through the superior mesenteric artery to the proximal sm

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Article · Sep 2005 · 1 min read

In brief

This neonatal piglet study demonstrates that GLP-2 infusion selectively increases blood flow to the proximal small intestine (duodenum and jejunum) in a dose-dependent manner, with greater effects on serosal versus mucosal layers. The findings reveal regional specificity of GLP-2's vasoactive effects, primarily mediated through the superior mesenteric artery, with implications for understanding gut adaptation during parenteral nutrition.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

Glucagon-like peptide-2 is a gut hormone that is secreted in response to enteral feeding and stimulates small intestinal mucosal growth.
Established
GLP-2 infusion at 500 pmol/kg/h for 2 hours increased duodenal blood flow by 77% compared with baseline in TPN-fed piglets.
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GLP-2 infusion at 500 pmol/kg/h for 2 hours increased jejunal blood flow by 40% compared with baseline in TPN-fed piglets.
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GLP-2 infusion at 2,000 pmol/kg/h for 2 hours increased jejunal blood flow by 80% compared with baseline in TPN-fed piglets.
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GLP-2 treatment did not change or slightly decreased blood flow to the distal small intestine and colon by 15%.
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Baseline mucosal blood flow was five-fold higher than serosal blood flow in TPN-fed piglets.
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High-dose GLP-2 treatment at 2,000 pmol/kg/h increased serosal blood flow by 140% and mucosal blood flow by 73%.
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High-dose GLP-2 at 2,000 pmol/kg/h increased pancreatic blood flow by 34%.
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High-dose GLP-2 at 2,000 pmol/kg/h decreased renal blood flow by 14%.
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High-dose GLP-2 at 2,000 pmol/kg/h decreased gastric blood flow by 12%.
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GLP-2 treatment did not affect blood flow in the spleen and brain.
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Acute GLP-2-mediated stimulation of portal blood flow in TPN-fed piglets occurs principally via increased blood flow through the superior mesenteric artery to the proximal small intestine.
Research