Gastroschisis: State of the Art in Translating Experimental Research to the Bedside
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In brief
In brief
Review of experimental gastroschisis models and their clinical translation. Despite improved survival, morbidity remains high due to intestinal dysfunction. Animal models have advanced understanding of pathophysiology and potential therapeutic interventions to reduce intestinal damage.
Written by the GCMD Library team from the article.
The survival rate of newborns with gastroschisis (GS) has been increasing in the past decades; however, the morbidity continues to be high, mainly related to the length of hospitalization due to disturbances of motility, absorption, and risk of intestinal infections. The development of basic research with the creation of experimental models has provided enormous advances in the understanding of the pathophysiology of the disease. These models allowed the study of the target genes involved in the embryology of the defect, the influence of the amniotic fluid, and the use of drugs and fetal therapies in an attempt to reduce the intestinal damage and to provide a rapid return of intestinal motility. Our aim was to describe the main GS models and the translational, historical impact of these research advances on the disease.