Gastroschisis Prognostic Score Successfully Identifies Brazilian Newborns with High-Risk Gastroschisis
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In brief
In brief
Prospective Brazilian study validates the Gastroschisis Prognostic Score in a middle-income setting, demonstrating that high-risk classification (GPS>2) successfully predicts prolonged parenteral nutrition, mechanical ventilation, and hospital stay in 61 newborns with gastroschisis treated 2015-2019.
Written by the GCMD Library team from the article.
Background
The Gastroschisis Prognostic Score (GPS) stratifies patients as high or low risk based on the visual assessment of intestinal matting, atresia, perforation, or necrosis. Despite being a simple score, its applicability to low and middle-income countries (LMICs) remains unknown. We tested the hypothesis that GPS can predict outcomes in LMICs, by assessing the prognostic value of the GPS in a middle-income country.
Methods
This prospective study followed all newborns with gastroschisis in a Brazilian neonatal unit based in a public hospital from 2015-2019. Infants were stratified into low and high-risk cohorts based on the GPS. In addition to basic demographics, data collected included duration of parenteral nutrition (TPN), mechanical ventilation (MV), length of stay (LOS), suspicion of infection that led to the use of antibiotics, and mortality. Univariate and multivariate analyses were conducted to identify which outcomes the GPS independently predicted.
Results
Sixty-one newborns with gastroschisis were treated during the study period. The mean birth weight, gestational age, and 5ʼ Apgar score were 2258g, 36 weeks, and 9. Twenty-four infants (39.3%) were identified as low-risk (GPS < 2) and 37 (60.7%) as high-risk (GPS > 2). The high-risk group presented with prolonged TPN use (p