Evaluation of Lung Injury in Infants with Congenital Diaphragmatic Hernia
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In brief
In brief
This retrospective study examines serum surfactant protein D (SP-D) as a biomarker for lung injury severity in 37 infants with congenital diaphragmatic hernia. Results demonstrate that elevated SP-D levels correlate with CDH severity, offering potential for objective assessment of pulmonary damage during clinical management.
Written by the GCMD Library team from the article.
Background/Purpose
The presence of lung injury and the factors that contribute to it in infants with congenital diaphragmatic hernia (CDH) have not been objectively measured during their clinical course. In adults with acute respiratory distress syndrome, higher serum levels of surfactant protein D (SP-D) are linked to lung injury and worse outcomes. We hypothesized that serum SP-D levels would be elevated in CDH infants and that the levels would correlate to the amount of lung injury present.
Methods
In this retrospective cohort study, serum SP-D levels were analyzed in 37 CDH infants and 5 control infants using a commercially available enzyme-linked immunosorbent assay kit.
Results
Infants with more severe CDH had a statistically significant increase (p