Epidemiology of gastroschisis: A population-based study in California from 1995 to 2012
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In brief
In brief
Population-based study of 4,831 gastroschisis cases in California (1995-2012) found prevalence of 2.7 per 10,000 live births. Significant associations identified with maternal exposure to noxious substances and low birthweight, though traditional substance exposures showed no difference from controls.
Written by the GCMD Library team from the article.
Background
Although the incidence of gastroschisis is increasing, risk factors are not clearly identified.
Methods
Using the Linked Birth Database from the California Office of Statewide Health Planning and Development from 1995 to 2012, patients with gastroschisis were identified by ICD-9 diagnosis/procedure code or birth certificate designation. Logistic regressions examined demographics, birth factors, and maternal exposures on risk of gastroschisis.
Results
The prevalence of gastroschisis was 2.7 cases per 10,000 live births. Patients with gastroschisis had no difference in fetal exposure to alcohol (p = 0.609), narcotics (p = 0.072), hallucinogenics (p = 0.239), or cocaine (p = 0.777), but had higher exposure to unspecified/other noxious substances (OR 3.27, p = 0.040; OR 2.02, p = 0.002). Gastroschisis was associated with low/very low birthweight (OR 5.08–16.21, p