Efficacy analysis of multidisciplinary treatment for Wilms tumor in a single center
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In brief
In brief
This single-center study of 68 children with Wilms tumor achieved an 87.4% five-year survival rate using multidisciplinary treatment. Cox analysis identified histological type as the sole independent prognostic factor, with unfavorable histology predicting poorer outcomes regardless of tumor volume, ethnicity, or recurrence status.
Written by the GCMD Library team from the article.
Abstract
Objective
To analyze the efficacy of multidisciplinary treatment for Wilms tumor (WT) in Kunming Children’s Hospital, and investigate the risk factors affecting the prognosis of WT.
Methods
The clinic-pathological data were collected and analyzed in patients with unilateral WT treated in Kunming Children's Hospital from January 2017 to July 2021. Research subjects were selected according to inclusion criteria and exclusion criteria. The risk factors and independent risk factors that affect the prognosis of patients with WT were determined by Kaplan–Meier survival analysis and Cox proportional hazards model, respectively.
Outcome
A total of 68 children were included in this study, and the 5-year overall survival (OS) rate was 87.4%. Kaplan–Meier survival analysis results showed that ethnicity (P = 0.020), the tumor volume of resection (P = 0.001), histological type (P < 0.001), and postoperative recurrence (P < 0.001) were the risk factors affecting the prognosis of children with WT. The results of the Cox proportional hazards model showed that only the histological type (P = 0.018) was the independent risk factor for the prognosis of WT.
Conclusion
The efficacy of multidisciplinary treatment for WT was satisfying. The histological type has important predictive value for the prognosis of WT, and the patient with unfavorable histology has a poor prognosis.